Dados do Trabalho

Título

Enhancing Immunological Responses in Non-Muscle Invasive Bladder Cancer: Effects of OncoTherad® (MRB-CFI-1) Immunotherapy on the Tumor Microenvironment, Focusing on Tumor-Associated Macrophages, Tumor-Infiltrating Lymphocytes and Monoamine Oxidases

Resumo

Non-muscle invasive bladder cancer (NMIBC) presents significant management challenges due to its high recurrence rate and a complex tumor microenvironment (TME) that often suppresses effective immune responses. This study investigated the effects of OncoTherad® (MRB-CFI1) nanoimmunotherapy on the TME of BCG-unresponsive NMIBC, specifically focusing on alterations in monoamine oxidases (MAO-A and MAO-B) and immune markers including CD163, FOXP3, CD8, and CX3CR1. We conducted a comparative analysis of immunoreactivities in bladder biopsies taken before and after OncoTherad® (MRB-CFI-1) treatment and established an immune score (IS) to evaluate the correlation between immunological changes and clinical outcomes. Forty formalin-fixed, paraffin-embedded bladder tissue samples from 20 patients, aged 44 to 83 years (mean 63.5 years), who were diagnosed with BCG-unresponsive NMIBC e, posteriormente tratados com OncoTherad® (MRB-CFI-1). Bladder biopsies of each patient were divided into 2 groups (n= 20 samples per group): Group 1 (initial biopsy, before OncoTherad treatment); and Group 2 (bladder biopsy after OncoTherad treatment). Our results showed stable MAO-A levels but a significant (p

Palavras Chave

Bladder cancer; tumor microenvironment; immunotherapy